Copa Airlines ni agahebuzo kubwa yatangajwe mu Panama. Ni umuyobozi w'abahatanira mu Pannama ndetse n'ita mbi y'igihugu, ibanda itangira agace ka mugoroba ko mu Burengerazuba. Copa Airlines yatangiye mu mwaka w'1947 ndetse itarenze ruzinduka imirongo mikuru mu gihugu cya Amerika y'Epfo. Ni umushyikirano wa Star Alliance, umuyobozi w'abahatanira mu iterambere ry'imyuga iyanditswe. Copa Airlines itanga abaterankunga batandukanye, ibitunga bitarenze ibibare birenze Boeing 737s n'Embraer 190s, n'igice cy'imirimo itanga abavohereza ku cyabahezaga, nk'amafaranga azaharanira mu ndege, Wi-Fi ku byerekezo byayo, n'iby'amategeko ameze neza ye yokwitabirwa zawuhanga kugirango aba abavohereze bo bategekesha ibyo bakoze, ikaba icaye ifumba ConnectMiles. Umuyobozi ushobora kufata icyemezo gishobora kugirango agereke berekana amahugurwa agiranye namaziriye, nkuko kuwuhanganira "Umuhazi w'Abaterankunga muri Amerika y'Epfo n'ibiregagazigwe" na Skytrax. Copa Airlines yaweza ahantu hose muri Amerika y'Epfo, Ndaruda n'Imibuha, n'abasubiramwo kubahiriza ku ntebe yawo i Tocumen International Airport mu Mujyi wa Panama.